Calling cell biologists to try cryo-ET
Nature Methods | July 31, 2018 Cryo-electron tomography (cryo-ET) advances can ease the path to 3D renderings of cellular architecture.
Bdellovibrio bacteriovorus
Gram-negative bacteria, like Escherichia coli and Salmonella species, can wreak havoc on their human hosts when they develop antibiotic resistance. But even bacteria that can chuck out antibiotics can’t defend against this tiny hunter, the small prokaryote Bdellovibrio bacteriovorus. Like its prey, Bdellovibrio is also a gram-negative bacterium. It can replicate either on its own […]
Pyruvate Dehydrogenase
This image shows the inner and outer shells of the large protein machine pyruvate dehydrogenase, which converts pyruvate (derived from sugars like glucose) into acetyl-coA. This is one of many steps necessary for a cell to generate energy, and also provides the building blocks for a variety of molecules that are recycled and reused by […]
How the ubiquitous GPCR receptor family selectively activates signalling pathways
Nature News and Views | June 27, 2018 G-protein-coupled receptors activate different G-protein types to trigger divergent signalling pathways. Four structures of receptor–G-protein complexes shed light on this selectivity.
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Kang, Y, Kuybeda, O, de Waal, PW, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, XE, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Ernst, OP, Kossiakoff, AA, Subramaniam, S, Xu, HE.
Nature 558(7711), 553-558. (2018)
Deep-learning-assisted Volume Visualization
Cheng H-C, Cardone A, Jain S, Krokos E, Narayan K, Subramaniam S, Varshney A. IEEE Transactions on Visualization and Computer Graphics 25: 1378-91 (2018)
Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N
Chittori S, Hong J, Saunders H, Feng H, Ghirlando R, Kelly AE, Bai Y, Subramaniam S. Science 359: 339-43 (2018)