Publications
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AlignPCA-2D: PCA-Reduced Euclidean Vector Alignment for 2D Classification in Cryo-EM
Ramírez-Aportela E, Lauzirika OL, Fonseca YC, Ceska T, Subramaniam S, Carazo JM, Sorzano COS.
Acta Crystallographica Section D (2026) | In Press

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Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor
Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Dos Santos N, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk AM, Cholak S, Merk A, Cameron DR, Subramaniam S.
IUCrJ (2026) | In Press

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Cryo-EM analysis of cooperative conformational changes in the SARS-CoV-2 spike protein trimer
Wang Q, Cholak S, Woollard G, Subramaniam S, Dao Duc K.
IUCrJ (2026) | In Press

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Cryo-EM: The revolution continues
Subramaniam S, Kuhlbrandt W, Henderson R.
IUCrJ (2026) | In Press

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Mutations in VCP cause Adams-Oliver syndrome with or without pulmonary hypertension
Lehman A, Ahmed S, Mohajeri A, Yang GX, Berezuk AM, Mannar D, Cholak S, Tuttle K, Bennett JT, Magno JA, Hannibal M, Kovacevic G, Kuburović V, Suzanne Lewis ME, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS.

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Loss of α2,3-linked sialoside in the receptor-binding site of a H5N1 influenza hemagglutinin identified in a human patient
Ni JH, Malek Zadeh S, Berezuk AM, Lynam R, Axerio-Cilies P, Zhu X, Tuttle KS, Owen G, Tokuyama M, Subramaniam S.

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Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells
Hu L, Lin J, Sun L, Berezuk AM, Tuttle KS, Zhu X, Seo H, Dhe-Paganon S, Li P, Sun Y, Ni L, Zhang J, Tan D, Wakimoto H, Cahill DP, Bai X, Luo X, Asara JM, Subramaniam S, Shan Y, Wu X.

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Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future
Subramaniam S, Saville JW, Feng F, Freiburger L.

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SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain
Halvorson T, Ivison S, Huang Q, Ladua G, Yotis DM, Mannar D, Subramaniam S, Ferreira VH, Kumar D, Belga S, Levings MK; PREVenT Study Group.

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Community recommendations on cryoEM data archiving and validation
Kleywegt GJ, Adams PD, Butcher SJ, Lawson CL, Rohou A, Rosenthal PB, Subramaniam S, Topf M, Abbott S, Baldwin PR, Berrisford JM, Bricogne G, Choudhary P, Croll TI, Danev R, Ganesan SJ, Grant T, Gutmanas A, Henderson R, Heymann JB, Huiskonen JT, Istrate A, Kato T, Lander GC, Lok SM, Ludtke SJ, Murshudov GN, Pye R, Pintilie GD, Richardson JS, Sachse C, Salih O, Scheres SHW, Schroeder GF, Sorzano COS, Stagg SM, Wang Z, Warshamanage R, Westbrook JD, Winn MD, Young JY, Burley SK, Hoch JC, Kurisu G, Morris K, Patwardhan A, Velankar S.
