Publications
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AlignPCA-2D: PCA-Reduced Euclidean Vector Alignment for 2D Classification in Cryo-EM
Ramírez-Aportela E, Lauzirika OL, Fonseca YC, Ceska T, Subramaniam S, Carazo JM, Sorzano COS.
Acta Crystallographica Section D (2026) | In Press
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Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor
Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Dos Santos N, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk AM, Cholak S, Merk A, Cameron DR, Subramaniam S.
IUCrJ (2026) | In Press
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Cryo-EM analysis of cooperative conformational changes in the SARS-CoV-2 spike protein trimer
Wang Q, Cholak S, Woollard G, Subramaniam S, Dao Duc K.
IUCrJ (2026) | In Press
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Cryo-EM: The revolution continues
Subramaniam S, Kuhlbrandt W, Henderson R.
IUCrJ (2026) | In Press
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VCP variants cause Adams-Oliver syndrome with or without pulmonary hypertension
Lehman A, Ahmed S, Mohajeri A, Yang GX, Berezuk AM, Mannar D, Cholak S, Tuttle K, Bennett JT, Magno JA, Hannibal M, Kovacevic G, Kuburović V, Suzanne Lewis ME, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS.
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Loss of α2,3-linked sialoside in the receptor-binding site of a H5N1 influenza hemagglutinin identified in a human patient
Ni JH, Malek Zadeh S, Berezuk AM, Lynam R, Axerio-Cilies P, Zhu X, Tuttle KS, Owen G, Tokuyama M, Subramaniam S.
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Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells
Hu L, Lin J, Sun L, Berezuk AM, Tuttle KS, Zhu X, Seo H, Dhe-Paganon S, Li P, Sun Y, Ni L, Zhang J, Tan D, Wakimoto H, Cahill DP, Bai X, Luo X, Asara JM, Subramaniam S, Shan Y, Wu X.
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Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future
Subramaniam S, Saville JW, Feng F, Freiburger L.
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SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain
Halvorson T, Ivison S, Huang Q, Ladua G, Yotis DM, Mannar D, Subramaniam S, Ferreira VH, Kumar D, Belga S, Levings MK; PREVenT Study Group.
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Community recommendations on cryoEM data archiving and validation
Kleywegt GJ, Adams PD, Butcher SJ, Lawson CL, Rohou A, Rosenthal PB, Subramaniam S, Topf M, Abbott S, Baldwin PR, Berrisford JM, Bricogne G, Choudhary P, Croll TI, Danev R, Ganesan SJ, Grant T, Gutmanas A, Henderson R, Heymann JB, Huiskonen JT, Istrate A, Kato T, Lander GC, Lok SM, Ludtke SJ, Murshudov GN, Pye R, Pintilie GD, Richardson JS, Sachse C, Salih O, Scheres SHW, Schroeder GF, Sorzano COS, Stagg SM, Wang Z, Warshamanage R, Westbrook JD, Winn MD, Young JY, Burley SK, Hoch JC, Kurisu G, Morris K, Patwardhan A, Velankar S.
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Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein
Mannar D, Saville JW, Poloni C, Zhu X, Berezuk A, Tidey K, Ahmed S, Tuttle KS, Vahdatihassani F, Cholak S, Cook L, Steiner TS, Subramaniam S.
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AAA ATPase protein-protein interactions as therapeutic targets in cancer
Mannar D, Ahmed S, Subramaniam S.
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Structural biology in the age of AI
Subramaniam S.
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Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
Marcus K, Huang Y, Subramanian S, Gee CL, Gorday K, Ghaffari-Kashani S, Luo XR, Zheng L, O’Donnell M, Subramaniam S, Kuriyan J.
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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold
Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JÉ, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO.
Proceedings of the National Academy of Sciences USA 120: e2305494120 (2023)
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Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives
Cholak S, Saville JW, Zhu X, Berezuk AM, Tuttle KS, Haji-Ghassemi O, Alvarado FJ, Van Petegem F, Subramaniam S.
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Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein
Saville JW, Mannar D, Zhu X, Berezuk AM, Cholak S, Tuttle KS, Vahdatihassani F, Subramaniam S.
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Learning from Gobind Khorana: “The difficult we do today, the impossible tomorrow”
Subramaniam S.
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Cryo-EM at ACA 2022
Subramaniam S, Kotecha A, Davis JH.
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Introduction: Cryo-EM in Biology and Materials Research
Subramaniam S, Danino D.
