The success of our efforts to use electron microscopy to accelerate drug discovery and understand cellular mechanisms rely heavily on developing methods to obtain the most information from the use of electron imaging. Our active program to advance the frontier of electron microscopy has enabled us to achieve some of the highest resolutions possible using single particle cryo-EM as well as new advances in subcellular correlative imaging with focused ion beams and forays into chemical imaging of whole cells.
Recent breakthroughs in the field of cryo-electron microcopy (cryo-EM) provide new prospects for analysis of protein structures. The prospect that the determination of protein structures at atomic resolution will no longer be limited by size, or by the need for crystallization, represents an exciting horizon in structural biology. Our interest in this area is focused on structural biology of small dynamic enzymes, membrane proteins and nucleic acid-protein complexes relevant to cancer and neuroscience.