Cryo-EM Structure of a Dimeric B-Raf:14-3-3 Complex Reveals Asymmetry in the Active Sites of B-Raf Kinases
Science in the City | September 26, 2019 This week we profile a recent publication in Science from the laboratory of Dr. Sriram Subramaniam at UBC.
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
Kondo Y, Ognjenović J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J. Science 366: 109-15 (2019)
The final cut: Cas9 editing
Nature News & Views | July 8, 2019 The ability of CRISPR-Cas9 to accurately and efficiently target and cleave any segment of double-stranded DNA based solely on the sequence of its loaded guide RNA has revolutionized genome editing.
UBC scientists capture images of gene-editing enzymes in action
UBC News | July 8, 2019 Findings hold promise for future treatment of human diseases caused by DNA mutations.
Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9
Zhu X, Clarke R, Puppala AK, Chittori S, Merk A, Merrill BJ, Simonovic M, Subramaniam S. Nature Structural & Molecular Biology 26: 679-85 (2019)