B-Raf

B-raf protein as a purple and teal pair ontop of the 14-3-3 platform

Cryo-EM Structure of a Dimeric B-Raf:14-3-3 Complex Reveals Asymmetry in the Active Sites of B-Raf Kinases

Science in the City | September 26, 2019 This week we profile a recent publication in Science from the laboratory of Dr. Sriram Subramaniam at UBC.

Structure of B-Raf dimer bound to the 14-3-3 complex, where one protomer inserts its c-terminal tail into the active site of its neighbour

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

Kondo Y, Ognjenović J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J. Science 366: 109-15 (2019)