Publications

  • Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains

    Chen C, Saville JW, Marti MM, Schäfer A, Cheng MH, Mannar D, Zhu X, Berezuk AM, Banerjee A, Sobolewski MD, Kim A, Treat BR, Castanha PMDS, Enick N, McCormick KD, Liu X, Adams C, Hines MG, Sun Z, Chen W, Jacobs JL, Barratt-Boyes SM, Mellors JW, Baric RS, Bahar I, Dimitrov DS, Subramaniam S, Martinez DR, Li W.

    iScience 25: 104798 (2022)

  • Imaging Cellular Architecture in Three Dimensions Through Electron Microscopy

    Caffrey B, Subramaniam S.

    Encyclopedia of Cell Biology, Second Edition (2022)

  • SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

    Mannar D, Saville JW, Sun Z, Zhu X, Marti MM, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Sobolewski MD, Kim A, Treat BR, Castanha PMDS, Jacobs JL, Barratt-Boyes SM, Mellors JW, Dimitrov DS, Li W, Subramaniam S.

    Nature Communications 13: 4696 (2022)

  • Three-Dimensional Visualization of Viral Structure, Entry, and Replication Underlying the Spread of SARS-CoV-2

    Saville JW, Berezuk AM, Srivastava SS, Subramaniam S.

    Chemical Reviews 122: 14066–84 (2022)

  • Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

    Fraser BJ, Beldar S, Seitova A, Hutchinson A, Mannar D, Li Y, Kwon D, Tan R, Wilson RP, Leopold K, Subramaniam S, Halabelian L, Arrowsmith CH, Bénard F.

    Nature Chemical Biology 18: 963-71 (2022)

  • Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

    Saville JW, Mannar D, Zhu X, Srivastava SS, Berezuk AM, Demers JP, Zhou S, Tuttle KS, Sekirov I, Kim A, Li W, Dimitrov DS, Subramaniam S.

    Nature Communications 13: 742 (2022)

  • SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

    Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Tuttle KS, Marquez C, Sekirov I, Subramaniam S. 

    Science 375: 760-64 (2022)

  • A paradigm shift in structural biology

    Subramaniam S, Kleywegt GJ.

    Nature Methods 19: 20-23 (2022)

  • Comparison of side-chain dispersion in protein structures determined by cryo-EM and X-ray crystallography

    Ravikumar A, Gopnarayan MN, Sriram Subramaniam S, Srinivasan N.

    IUCrJ 9: 98-103 (2022)

  • Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding

    Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Kim A, Li W, Dimitrov DS, Subramaniam S.

    Cell Reports 37: 110156 (2021)

  • A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

    Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J.

    eLife 10: 73218 (2021)

  • AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation

    Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S.

    Journal of Biological Chemistry 297: 101187 (2021)

  • New insights into Raf regulation from structural analyses

    Kondo Y, Paul JW III, Subramaniam S, Kuriyan J.

    Current Opinion in Structural Biology 71: 223–31 (2021)

  • Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry

    Mannar D, Leopold K, Subramaniam S.

    Scientific Reports 11: 12448 (2021)

  • Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

    Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.

    PLoS Biology 19: 3001237 (2021)

  • Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

    Schureck MA, Darling JE, Merk A, Shao J, Daggupati G, Srinivasan P, Olinares PDB, Rout MP, Chait BT, Wollenberg K, Subramaniam S, Desai SA.

    eLife 10: e65282 (2021)

  • Visualizing Cancer

    Krummel M, Hu K, de Vries EGE, Goetz JG, Passaro D, Subramaniam S, Misteli T, Skala M, Bravo-Cordero JJ, Sutcliffe JL.

    Cancer Cell 38: 753-56 (2020)

  • High Potency of a Bivalent Human Vh Domain in SARS-CoV-2 Animal Models

    Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS.

    Cell 183: 429-41 (2020)

  • COVID-19 and cryo-EM

    Subramaniam S.

    IUCrJ 7: 575-76 (2020)

  • 1.8 Å resolution structure of β-galactosidase with a 200 kV CRYO ARM electron microscope

    Merk A, Fukumura T, Zhu X, Darling JE, Grisshammer R, Ognjenovic J, Subramaniam S.

    IUCrJ 7: 639-43 (2020)