Molecular Pharmacology

Molecular Pharmacology Jun 2016, Vol. 89, No. 6 Read the Abstract

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Merk A, Bartesaghi A, Banerjee S, Falconieri V, Rao P, Davis M, Pragani R, Boxer M, Earl LA, Milne JLS, Subramaniam S. Cell 165: 1698-1707 (2016)

Cryo-EM analysis of the conformational landscape of human P-glycoprotein (ABCB1) during its catalytic cycle

Cryo-EM analysis of the conformational landscape of human P-glycoprotein (ABCB1) during its catalytic cycle

Frank GA, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S. Molecular Pharmacology 90: 35-41 (2016)

Using cryo-EM to map small ligands on dynamic metabolic enzymes: studies with glutamate dehydrogenase

Using cryo-EM to map small ligands on dynamic metabolic enzymes: studies with glutamate dehydrogenase

Borgnia MJ, Banerjee S, Merk A, Matthies D, Bartesaghi A, Rao P, Pierson J, Earl LA, Falconieri V, Subramaniam S, Milne JLS. Molecular Pharmacology 89: 645-51 (2016)

An sample picture, whats' this

Cryo-electron microscopy structures of chimeric hemagglutinin displayed on a universal influenza vaccine candidate

Tran EEH, Podolsky KA, Bartesaghi A, Kuybeda O, Grandinetti G, Wohlbold TJ, Tan GS, Nachbagauer R, Palese P, Krammer F, Subramaniam S. American Society for Microbiology 7: e00257-16 (2016)

Cryo-EM structures of the magnesium channel CorA reveal symmetry break upon gating

Cryo-EM structures of the magnesium channel CorA reveal symmetry break upon gating

Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, Reddy BG, Islam S, Bartesaghi A, Perozo E, Subramaniam S. Cell 164: 747-56 (2016)

The crystal structure of human GlnRS provides basis for the development of neurological disorders

The crystal structure of human GlnRS provides basis for the development of neurological disorders

Ognjenović J, Wu J, Matthies D, Baxa U, Subramaniam S, Ling J, Simonović M. Nucleic Acids Research 44: 3420-31 (2016)

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JLS, Huryn D, Arkin M, Subramaniam S. Science 351: 871-75 (2016)

CryoEM at IUCrJ: a new era

CryoEM at IUCrJ: a new era

Subramaniam S, Kühlbrandt W, Henderson R. IUCrJ 3: 3-7 (2016)

Focused ion beams in biology

Focused ion beams in biology

Narayan K, Subramaniam S. Nature Methods 12: 1021-31 (2015)