Subramaniam Lab awarded Rapid Response Funding for COVID Research
GenomeBC | April 30, 2020 Structure-guided design of therapeutics and antibodies against COVID-19
UBC discovery opens new avenues for designing drugs to combat drug-resistant malaria
EurekAlert! | April 30, 2020 The finding, recently published in the International Union of Crystallography Journal (IUCrJ), brings researchers one step closer to developing new therapies to combat drug-resistant malaria
Host membrane lipids are trafficked to membranes of intravacuolar bacterium Ehrlichia chaffeensis
Lin M, Grandinetti G, Hartnell LM, Bliss D, Subramaniam S, Rikihisa Y. Proceedings of the National Academy of Sciences USA 117: 8032-43 (2020)
Subramaniam Lab listed as one of key groups working on COVID-19 at UBC
Subramaniam Lab listed as one of key groups working on COVID-19 at UBC
Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures
Srivastava SS, Darling JE, Suryadi J, Morris JC, Drew ME, Subramaniam S. IUCrJ 7: 453-61 (2020)
Imaging Proteins Using Electrons
Imaging with electrons allows researchers to discern atomic details of large, complex molecules like proteins. During the imaging process, the interaction of electrons with the molecules being imaged inflicts damage that can alter the structure. Cryogenic temperatures (cryo-EM) can reduce the extent of this damage, but as we showed in a recent study, some parts […]
Visualizing Proteins with Cryo-EM
This image displays a number of the critical elements for determining the structure of a protein by cryo-electron microscopy. First, a solution containing many identical copies of a protein are spread on a grid (upper left), and quickly frozen to liquid nitrogen temperatures. These are imaged with an electron beam (teal), producing black-and-white images showing […]
Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
Sherekar M, Han SW, Ghirlando R, Messing S, Drew M, Rabara D, Waybright T, Juneja P, O’Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV, Gillette W, McCormick F, Esposito D. Journal of Biological Chemistry 295: 1105-19 (2020)