Drug Design

 

Recent breakthroughs in the field of cryo-electron microcopy (cryo-EM) provide new prospects for analysis of protein structures. The prospect that the determination of protein structures at atomic resolution will no longer be limited by size, or by the need for crystallization, represents an exciting horizon in structural biology. Our interest in this area is focused on structural biology of small dynamic enzymes, membrane proteins and nucleic acid-protein complexes relevant to cancer and neuroscience.