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Chemical Imaging

Chemical Imaging

What if you could point at a specific spot in a cell or tissue and know precisely what molecules were there, irrespective of labeling, fluorescence or chemistry? In an article published in the January 26, 2011, edition of Analytical Chemistry, Szakal and colleagues demonstrated that mass spectrometry, paired with a focused beam of gallium ions, […]

Calling cell biologists to try cryo-ET

Calling cell biologists to try cryo-ET

Nature Methods | July 31, 2018 Cryo-electron tomography (cryo-ET) advances can ease the path to 3D renderings of cellular architecture.

Bdellovibrio bacteriovorus

Bdellovibrio bacteriovorus

Gram-negative bacteria, like Escherichia coli and Salmonella species, can wreak havoc on their human hosts when they develop antibiotic resistance. But even bacteria that can chuck out antibiotics can’t defend against this tiny hunter, the small prokaryote Bdellovibrio bacteriovorus. Like its prey, Bdellovibrio is also a gram-negative bacterium. It can replicate either on its own […]

Pyruvate Dehydrogenase

Pyruvate Dehydrogenase

This image shows the inner and outer shells of the large protein machine pyruvate dehydrogenase, which converts pyruvate (derived from sugars like glucose) into acetyl-coA. This is one of many steps necessary for a cell to generate energy, and also provides the building blocks for a variety of molecules that are recycled and reused by […]